This page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
Protein Interactions
I analyzed the protein-protein interactions of CDKN2A using STRING 9.0. The two webs shown below are interaction webs of CDKN2A in humans with different levels of interactions. These views are shown in what is known as evidence view. A legend is provided with different colors indicating different kinds of evidence. A table is provided below the webs listing CDKN2A's interaction proteins. All images were provided by STRING 9.0.
Analysis
The proteins shown above are predicted to interact with CDKN2A in humans. The table briefly describes the proteins, which range from an interacting score of 0.999 to 0.984. I find the interaction of CDKN2A with CDK4 to be particularly interesting in terms of melanoma development and cell cycle control, as can be seen in the table.