This page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
Phylogeny of the Protein
The homologs of the CDKN2A protein in Homo sapiens were identified and phylogenically mapped in Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Danio rerio, Mus musculus, Pan troglodytes, Bos taurus and Rattus norvegicus.
This first tree was generated using Phylogeny.fr
This first tree was generated using Phylogeny.fr
This tree was generated using ClustalW2
Analysis
The two trees created using the homologous proteins of the nine previously mentioned organisms vary in their structure as well as the actual phylogeny of the proteins. The first tree created with Phylogeny.fr shows C. elegans as being the first organism to branch off where as the ClustalW2 tree shows A. thaliana as being the first. Both trees show the same branching pattern of the five most recent organisms which include M. musculus, R. norvegicus, B. taurus, P. troglodytes, and H. sapiens. As one would assume, the proteins in M. musculus and R. norvegicus are very phylogenically similar are are the proteins in P. troglodytes and H. sapiens.